Chemical formula – C6H22NO2

Drug class synthetic opioid analgesic

Trade name  - Ultram    

 

USES -

  • It is an analgesic used to treat mild to moderate pain.
  • Also indicated in chronic pain.
  • Mostly used in injected form.
  • Injected IV 100mg tramadol is equal to 10 mg IM morphine.

 

Advantage -

Quick action if given intravenous.

Tramadol causes less respiratory depression, sedation, constipation, urinary retention than morphine.

 

Side effects

  • Constipation
  • Urinary retention
  • Nausea
  • Itchiness
  • Kidney and liver problems

 

 

The drug is metabolized in liver and half-life is 5 hours , duration of action is 6 hours . Excretion is through urine  and Bioavailability is 75% by mouth and 100% IM

 

Dose-

50-100 mg oral, intramuscular or slow intravenous infusion.

Children- 1-2 mg per kg 4-6 hourly.

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  • This drug is centrally acting analgesic relieves pain by opioid as well as additional mechanisms.Its affinity for μ opioid receptor is low, while that for Δ and k receptor is very low.Its analgesic action is partially reversed by the opioid antagonist naloxone.